Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties

被引：5
|
作者：
Menia, Daniel [1 ]
Kopacka, Holger [1 ]
Wurst, Klaus [1 ]
Mueller, Thomas [2 ]
Lippmann, Petra [3 ]
Ott, Ingo [3 ]
Bildstein, Benno [1 ]
机构：
[1] Univ Innsbruck, Inst Gen Inorgan & Theoret Chem, Ctr Chem & Biomed, Innrain 80-82, A-6020 Innsbruck, Austria
[2] Univ Innsbruck, Inst Organ Chem, Ctr Chem & Biomed, Innrain 80-82, A-6020 Innsbruck, Austria
[3] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Beethovenstr 55, D-38106 Braunschweig, Germany
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2021年 / 2021卷 / 27期
基金：
奥地利科学基金会;
关键词：
Cobalt; Selenium; Gold; Sandwich complexes; Cytotoxicity; N-HETEROCYCLIC CARBENES; CHEMISTRY;
D O I：
10.1002/ejic.202100379
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Cobaltoceniumselenolate is an unusual, highly air-sensitive, mesoionic compound containing a very soft anionic selenium donor atom. Here we explore its coordination chemistry with Au(I) metal centers and show that its hetero- and homoleptic gold complexes are highly colored, air-stable compounds, which were characterized by H-1/C-13/P-31/Se-77 NMR, IR, UV-Vis, HR-MS and single crystal XRD. Cytotoxicity of these polar, water-soluble complexes was studied against various standard cancer cell lines (A549MDA-MB-231, HT-29) revealing good anticancer activity of all three complexes.
引用
收藏
页码：2784 / 2786
页数：3
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