Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties

被引：5

作者：

Menia, Daniel ^{[1
]}

Kopacka, Holger ^{[1
]}

Wurst, Klaus ^{[1
]}

Mueller, Thomas ^{[2
]}

Lippmann, Petra ^{[3
]}

Ott, Ingo ^{[3
]}

Bildstein, Benno ^{[1
]}

机构：

[1] Univ Innsbruck, Inst Gen Inorgan & Theoret Chem, Ctr Chem & Biomed, Innrain 80-82, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, Inst Organ Chem, Ctr Chem & Biomed, Innrain 80-82, A-6020 Innsbruck, Austria

[3] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Beethovenstr 55, D-38106 Braunschweig, Germany

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2021年 / 2021卷 / 27期

基金：

奥地利科学基金会;

关键词：

Cobalt; Selenium; Gold; Sandwich complexes; Cytotoxicity; N-HETEROCYCLIC CARBENES; CHEMISTRY;

D O I：

10.1002/ejic.202100379

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cobaltoceniumselenolate is an unusual, highly air-sensitive, mesoionic compound containing a very soft anionic selenium donor atom. Here we explore its coordination chemistry with Au(I) metal centers and show that its hetero- and homoleptic gold complexes are highly colored, air-stable compounds, which were characterized by H-1/C-13/P-31/Se-77 NMR, IR, UV-Vis, HR-MS and single crystal XRD. Cytotoxicity of these polar, water-soluble complexes was studied against various standard cancer cell lines (A549MDA-MB-231, HT-29) revealing good anticancer activity of all three complexes.

引用

页码：2784 / 2786

页数：3

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