Assessment of the diagnostic value of RT-PCR on amniotic fluid for prenatal diagnosis of congenital rubella infection

被引：2

作者：

Macé, M

Cointe, D

Six, C

Levy-Bruhl, D

du Chatelet, IP

Ingrand, D

Grangeot-Keros, L ^{[1
]}

机构：

[1] Hop Antoine Beclere, Serv Microbiol Immunol Biol, F-92141 Clamart, France

[2] Inst Veille Sanitaire, St Maurice, France

来源：

PATHOLOGIE BIOLOGIE | 2004年 / 52卷 / 09期

关键词：

rubella infection; confirmed primary rubella infection; prenatal diagnosis; amniotic fluid sample; RT-PCR;

D O I：

10.1016/j.patbio.2004.06.004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Aim of the study. - To assess the diagnostic value of RT-PCR on amniotic fluid (AF) for prenatal diagnosis of congenital rubella infection. Material and methods. - RT-PCR on AF was compared to specific IgM antibody detection in foetuses and/or newborns in 45 pregnant women with confirmed primary infection. Results. - specificity of RT-PCR was 100% and sensitivity ranged between 83 and 95%. Conclusion. - RT PCR may be considered as a valuable tool for prenatal diagnosis of foetal rubella infection. (C) 2004 Elsevier SAS. Tous droits reserves.

引用

页码：540 / 543

页数：4

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