Assessment of the diagnostic value of RT-PCR on amniotic fluid for prenatal diagnosis of congenital rubella infection

被引：2
|
作者：
Macé, M
Cointe, D
Six, C
Levy-Bruhl, D
du Chatelet, IP
Ingrand, D
Grangeot-Keros, L [1 ]
机构：
[1] Hop Antoine Beclere, Serv Microbiol Immunol Biol, F-92141 Clamart, France
[2] Inst Veille Sanitaire, St Maurice, France
来源：
PATHOLOGIE BIOLOGIE | 2004年 / 52卷 / 09期
关键词：
rubella infection; confirmed primary rubella infection; prenatal diagnosis; amniotic fluid sample; RT-PCR;
D O I：
10.1016/j.patbio.2004.06.004
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Aim of the study. - To assess the diagnostic value of RT-PCR on amniotic fluid (AF) for prenatal diagnosis of congenital rubella infection. Material and methods. - RT-PCR on AF was compared to specific IgM antibody detection in foetuses and/or newborns in 45 pregnant women with confirmed primary infection. Results. - specificity of RT-PCR was 100% and sensitivity ranged between 83 and 95%. Conclusion. - RT PCR may be considered as a valuable tool for prenatal diagnosis of foetal rubella infection. (C) 2004 Elsevier SAS. Tous droits reserves.
引用
收藏
页码：540 / 543
页数：4
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