A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole

被引：19
|
作者：
Sarma, K. Narasimha [1 ]
Subha, M. C. S. [1 ]
Rao, K. Chowdoji [1 ]
机构：
[1] Sri Krishnadevaraya Univ, Dept Chem, Anantapur 515003, Andhra Pradesh, India
来源：
E-JOURNAL OF CHEMISTRY | 2010年 / 7卷 / 03期
关键词：
Acid hydrazide; Chalkones; Pyrazole derivatives of indole; Schiff bases; MICROWAVE-ASSISTED SYNTHESIS; ANTIBACTERIAL ACTIVITY;
D O I：
10.1155/2010/979401
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanol via the hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsituted-4,5-dihydropyrazol-1-yl)(1H-indol-5-yl) methanone (7a-h) in good yields. All the newly synthesized compounds are by elemental analysis and spectral studies and evaluated for antimicrobial activities.
引用
收藏
页码：745 / 750
页数：6
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