A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole

被引：19
|
作者：
Sarma, K. Narasimha [1 ]
Subha, M. C. S. [1 ]
Rao, K. Chowdoji [1 ]
机构：
[1] Sri Krishnadevaraya Univ, Dept Chem, Anantapur 515003, Andhra Pradesh, India
来源：
E-JOURNAL OF CHEMISTRY | 2010年 / 7卷 / 03期
关键词：
Acid hydrazide; Chalkones; Pyrazole derivatives of indole; Schiff bases; MICROWAVE-ASSISTED SYNTHESIS; ANTIBACTERIAL ACTIVITY;
D O I：
10.1155/2010/979401
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanol via the hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsituted-4,5-dihydropyrazol-1-yl)(1H-indol-5-yl) methanone (7a-h) in good yields. All the newly synthesized compounds are by elemental analysis and spectral studies and evaluated for antimicrobial activities.
引用
收藏
页码：745 / 750
页数：6
相关论文
共 50 条
  • [31] Synthesis and antibacterial activity of some new derivatives of pyrazole
    Mohammad Rahimizadeh
    Mehdi Pordel
    Mehdi Bakavoli
    Shima Rezaeian
    Ali Sadeghian
    World Journal of Microbiology and Biotechnology, 2010, 26 : 317 - 321
  • [32] Synthesis and antimicrobial activity of some new indole containing isoxazolines and phthalimidoxy derivatives of thiazolidinone and thiohydantoin
    Bhambi, Dinesh
    Salvi, Vijay K.
    Jat, Jawahar L.
    Ojha, Swati
    Talesara, Ganpat L.
    Journal of Sulfur Chemistry, 2007, 28 (02) : 155 - 163
  • [33] Recent Developments in the Synthesis and Antimicrobial Activity of Indole and its Derivatives
    Kaur, Jaskirat
    Utreja, Divya
    Ekta
    Jain, Nisha
    Sharma, Shivali
    CURRENT ORGANIC SYNTHESIS, 2019, 16 (01) : 17 - 37
  • [34] Synthesis of Pyrano, Pyrido, Oxazino, and Spiro Pyrazole Derivatives and Their Antimicrobial Activity
    E. F. Abdelrahman
    W. Shehta
    M. G. M. Assy
    M. E. Farhan
    Russian Journal of Organic Chemistry, 2020, 56 : 1832 - 1839
  • [35] Synthesis and characterization of selected fused isoxazole and pyrazole derivatives and their antimicrobial activity
    Dabholkar, Vijay V.
    Ansari, Faisal Y.
    JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2009, 74 (11) : 1219 - 1228
  • [36] SYNTHESIS AND SCREENING OF ANTIMICROBIAL ACTIVITY OF NOVEL PYRROLYL-PYRAZOLE DERIVATIVES
    Hallikeri, C. S.
    Joshi, Shrinivas D.
    Kumar, Devendra
    Kulkarni, V. H.
    Selvam, Theivendren Paneer
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 24 (03) : 261 - 264
  • [37] Synthesis of Pyrano, Pyrido, Oxazino, and Spiro Pyrazole Derivatives and Their Antimicrobial Activity
    Abdelrahman, E. F.
    Shehta, W.
    Assy, M. G. M.
    Farhan, M. E.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 56 (10) : 1832 - 1839
  • [38] Synthesis and antimicrobial activity evaluation of pyrazole derivatives containing imidazothiadiazole moiety
    Han, Lan-Ying
    Sun, Jing-Xin
    Liu, Chuang
    Ai, Bing
    Piao, Ming-Guan
    Zhang, Changhao
    Quan, Ji-Shan
    Jin, Cheng-Hua
    FUTURE MEDICINAL CHEMISTRY, 2025, 17 (02) : 157 - 170
  • [39] Synthesis, Docking Studies and Anticancer Activity of Some Pyrazole Derivatives
    Yadav, Amrita
    Kumar, Sushil
    Dwivedi, Navneet
    Gupta, Rajiv
    Singh, Narendra Kumar
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2024, 34 (04) : 453 - 458
  • [40] Synthesis and anti-inflammatory activity of some pyrazole derivatives
    El-Moghazy, Samir M.
    Barsoum, Flora F.
    Abdel-Rahman, Hamdy M.
    Marzouk, Adel A.
    MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (08) : 1722 - 1733
12345