Microwave assisted, palladium catalyzed aminocarbonylations of heteroaromatic bromides using solid Mo(CO)6 as the carbon monoxide source

被引：38
|
作者：
Letavic, Michael A. [1 ]
Ly, Kiev S. [1 ]
机构：
[1] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 13期
关键词：
D O I：
10.1016/j.tetlet.2007.01.133
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The direct conversion of a variety of heteroaromatic bromides into heteroaromatic amides is described. This reaction utilizes Mo(CO)(6) as the carbon monoxide source and is performed using microwave heating allowing for very short reaction times. This convenient methodology allows for the preparation of a variety of heteroaromatic amides useful in medicinal chemistry applications. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2339 / 2343
页数：5
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