New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation

被引：7
|
作者：
Badarau, Eduard [4 ]
Putey, Aurelien [2 ]
Suzenet, Franck [1 ]
Joseph, Benoit [2 ]
Bojarski, Andrzej [3 ]
Finaru, Adriana [4 ]
Guillaumet, Gerald
机构：
[1] Univ Orleans, Dept Chem, ICOA, F-45067 Orleans, France
[2] Univ Lyon, Lyon, France
[3] Polish Acad Sci, Krakow, Poland
[4] Univ Bacau, Fac Engn, Bacau, Romania
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2010年 / 25卷 / 03期
关键词：
Homopiperazinyl; 7-azaindole; 5-HT7; 5-HT1A receptor affinity; 5-HT7 RECEPTOR LIGANDS; ANTAGONISTS; AFFINITY; CYCLASE; CLONING;
D O I：
10.3109/14756360903179393
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of new N-homopiperazinyl-based ligands is reported. Various structural modifications along with the corresponding biological activities on 5-HT1A/5-HT7 receptors give further insights into this class of serotoninergic ligands. Among the tested central heterocyles, the 7-azaindole gave the best results on the above-mentioned receptors.</.
引用
收藏
页码：301 / 305
页数：5
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