New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation

被引：7

作者：

Badarau, Eduard ^{[4
]}

Putey, Aurelien ^{[2
]}

Suzenet, Franck ^{[1
]}

Joseph, Benoit ^{[2
]}

Bojarski, Andrzej ^{[3
]}

Finaru, Adriana ^{[4
]}

Guillaumet, Gerald

机构：

[1] Univ Orleans, Dept Chem, ICOA, F-45067 Orleans, France

[2] Univ Lyon, Lyon, France

[3] Polish Acad Sci, Krakow, Poland

[4] Univ Bacau, Fac Engn, Bacau, Romania

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2010年 / 25卷 / 03期

关键词：

Homopiperazinyl; 7-azaindole; 5-HT7; 5-HT1A receptor affinity; 5-HT7 RECEPTOR LIGANDS; ANTAGONISTS; AFFINITY; CYCLASE; CLONING;

D O I：

10.3109/14756360903179393

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of new N-homopiperazinyl-based ligands is reported. Various structural modifications along with the corresponding biological activities on 5-HT1A/5-HT7 receptors give further insights into this class of serotoninergic ligands. Among the tested central heterocyles, the 7-azaindole gave the best results on the above-mentioned receptors.</.

引用

页码：301 / 305

页数：5

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