LVV-hemorphin-7 lowers blood pressure in spontaneously hypertensive rats:: Radiotelemetry study

被引：20
|
作者：
Cejka, J
Zelezná, B
Velek, J
Zicha, J
Kuntes, J [1 ]
机构：
[1] Acad Sci Czech Republ, Inst Physiol, Videnska 1083, CR-14220 Prague, Czech Republic
[2] Acad Sci Czech Republ, Ctr Expt Res Cardiovasc Dis, CR-14220 Prague, Czech Republic
[3] Acad Sci Czech Republ, Inst Mol Genet, CR-14220 Prague, Czech Republic
[4] Acad Sci Czech Republ, Inst Organ Res Cardiovasc Dis, CR-14220 Prague, Czech Republic
[5] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-14220 Prague, Czech Republic
来源：
PHYSIOLOGICAL RESEARCH | 2004年 / 53卷 / 06期
关键词：
hemorphin; blood pressure; heart rate; hypertension; rat;
D O I：
10.33549/physiolres.930728
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Cardiovascular effects of LVV-hemorphin-7, a member of the family of fragments from beta-chain of human or bovine hemoglobin, were studied in conscious spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats by radiotelemetry. Intraperitoneal injection of hemorphin in a dose of 100 mug/kg significantly decreased blood pressure in SHR, whereas negligible effect was seen in normotensive WKY rats. Blood pressure changes were accompanied by reduction of heart rate. In conclusion, a direct effect of LVV-hemorphin-7 on blood pressure was demonstrated in SHR. These biologically active peptides could be involved in blood pressure regulation especially in hypertensive rats. but the precise mechanism should be elucidated.
引用
收藏
页码：603 / 607
页数：5
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