LVV-hemorphin-7 lowers blood pressure in spontaneously hypertensive rats:: Radiotelemetry study

被引：20

作者：

Cejka, J

Zelezná, B

Velek, J

Zicha, J

Kuntes, J ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Physiol, Videnska 1083, CR-14220 Prague, Czech Republic

[2] Acad Sci Czech Republ, Ctr Expt Res Cardiovasc Dis, CR-14220 Prague, Czech Republic

[3] Acad Sci Czech Republ, Inst Mol Genet, CR-14220 Prague, Czech Republic

[4] Acad Sci Czech Republ, Inst Organ Res Cardiovasc Dis, CR-14220 Prague, Czech Republic

[5] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-14220 Prague, Czech Republic

来源：

PHYSIOLOGICAL RESEARCH | 2004年 / 53卷 / 06期

关键词：

hemorphin; blood pressure; heart rate; hypertension; rat;

D O I：

10.33549/physiolres.930728

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Cardiovascular effects of LVV-hemorphin-7, a member of the family of fragments from beta-chain of human or bovine hemoglobin, were studied in conscious spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats by radiotelemetry. Intraperitoneal injection of hemorphin in a dose of 100 mug/kg significantly decreased blood pressure in SHR, whereas negligible effect was seen in normotensive WKY rats. Blood pressure changes were accompanied by reduction of heart rate. In conclusion, a direct effect of LVV-hemorphin-7 on blood pressure was demonstrated in SHR. These biologically active peptides could be involved in blood pressure regulation especially in hypertensive rats. but the precise mechanism should be elucidated.

引用

页码：603 / 607

页数：5

共 50 条

[21] Glucuronidated Quercetin Lowers Blood Pressure in Spontaneously Hypertensive Rats via Deconjugation
Galindo, Pilar
Rodriguez-Gomez, Isabel
Gonzalez-Manzano, Susana
Duenas, Montserrat
Jimenez, Rosario
Menendez, Carmen
Vargas, Felix
Tamargo, Juan
Santos-Buelga, Celestino
Perez-Vizcaino, Francisco
Duarte, Juan
PLOS ONE, 2012, 7 (03):
[22] Dietary vitamin E supplementation lowers blood pressure in spontaneously hypertensive rats
Vasdev, S
Gill, V
Parai, S
Longerich, L
Gadag, V
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2002, 238 (1-2) : 111 - 117
[23] Dietary α-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats
Vasdev, S
Ford, CA
Parai, S
Longerich, L
Gadag, V
JOURNAL OF HYPERTENSION, 2000, 18 (05) : 567 - 573
[24] A HIGH PHOSPHATE DIET LOWERS BLOOD-PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS
BINDELS, RJM
VANDENBROEK, LAM
HILLEBRAND, SJW
WOKKE, JMP
HYPERTENSION, 1987, 9 (01) : 96 - 102
[25] The hemoglobin derived peptide LVV-hemorphin-7 evokes behavioral effects mediated by oxytocin receptors
da Cruz, Kellen Rosa
Turones, Larissa Cordova
Camargo-Silva, Gabriel
Gomes, Karina Pereira
Mendonca, Michelle Mendanha
Galdino, Pablinny
Rodrigues-Silva, Christielly
Souza Santos, Robson Augusto
Costa, Elson Alves
Ghedini, Paulo Cesar
Ianzer, Danielle
Xavier, Carlos Henrique
NEUROPEPTIDES, 2017, 66 : 59 - 68
[26] Treatment with Ligilactobacillus murinus lowers blood pressure and intestinal permeability in spontaneously hypertensive rats
Mukohda, Masashi
Yano, Takanori
Matsui, Toshiyasu
Nakamura, Sho
Miyamae, Jiro
Toyama, Kensuke
Mitsui, Ryoji
Mizuno, Risuke
Ozaki, Hiroshi
SCIENTIFIC REPORTS, 2023, 13 (01)
[27] Dietary vitamin E supplementation lowers blood pressure in spontaneously hypertensive rats.
Vasdev, S
CLINICAL CHEMISTRY, 2002, 48 (06) : A75 - A75
[28] TYROSINE (TYR) INJECTION LOWERS BLOOD-PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)
SVED, AF
FERNSTROM, JD
WURTMAN, RJ
FEDERATION PROCEEDINGS, 1979, 38 (03) : 421 - 421
[29] RENAL MEDULLARY CAPTOPRIL DELIVERY LOWERS BLOOD-PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS
LU, SH
MATTSON, DL
COWLEY, AW
HYPERTENSION, 1994, 23 (03) : 337 - 345
[30] Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats
Ding, Liliqiang
Jia, Chenglin
Zhang, Yong
Wang, Wenjian
Zhu, Weiliang
Chen, Yu
Zhang, Teng
BIOMEDICINE & PHARMACOTHERAPY, 2019, 111 : 325 - 330

← 1 2 3 4 5 →