Synthesis and Characterization of Metabolites and Potential Impurities of Balsalazide Disodium, an Anti-Inflammatory Drug

被引：13
|
作者：
Khan, Md Umar [2 ]
Baseer, M. A. [2 ]
Kumar, S. Ranjith
Saravanakumar, M.
Prasannanjali, A. G.
Gupta, P. Badarinadh
Kaushik, Vipin K.
Handa, Vijay K.
Islam, Aminul [1 ]
机构：
[1] Aurobindo Pharma Ltd, APL Res Ctr, Chem Res & Dev Dept, Chem R&D, Hyderabad 500072, Andhra Pradesh, India
[2] Yeshwant Mahavidyalaya, Organ Chem Res Lab, Nanded, India
来源：
SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 15期
关键词：
5-Aminosalicylic acid; balsalazide; diazo coupling; impurities; synthesis; 5-AMINOSALICYLIC ACID ENEMAS; ULCERATIVE-COLITIS; SULFASALAZINE; MESALAZINE; DISEASE;
D O I：
10.1080/00397910903221068
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Balsalazide disodium (Colazide (R)) is an oral prodrug of mesalamine (5-aminosalicylic acid) and possesses anti-inflammatory properties. During the process development for balsalazide disodium, we observed eight impurities, namely des--alanine balsalazide, balsalazide -alanine, balsalazide 3-isomer, decarboxy balsalazide, bis-azo salicylic acid, biphenyl-azo salicylic acid, bis-azo diacid, and bis-azo triacid. The present work describes the synthesis and characterization of these impurities.
引用
收藏
页码：2241 / 2253
页数：13
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