Synthesis and characterization of metabolites and potential impurities of lansoprazole, an antiulcerative drug

被引：12
|
作者：
Reddy, Ganta Madhusudhan [2 ]
Mukkanti, K. [2 ]
Kumar, T. Laxmi
Babu, J. Moses
Reddy, Padi Pratap [1 ]
机构：
[1] Dr Reddys Labs Ltd, Res & Dev, Act Pharmaceut Ingredients, Integrated Prod Dev, Hyderabad 500072, Andhra Pradesh, India
[2] JNT Univ, Inst Sci & Technol, Hyderabad, Andhra Pradesh, India
来源：
SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 20期
关键词：
HR-MS; impurities; lansoprazole; spectral characterization; synthesis;
D O I：
10.1080/00397910802162934
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Lansoprazole (Prevacid) is an antiulcerative drug used for the treatment of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger-Ellison syndrome. During the bulk synthesis of lansoprazole, we have observed five impurities: lansoprazole N-oxide, lansoprazole sulfone N-oxide, lansoprazole sulfide, lansoprazole sulfone and N-aralkyl lansoprazole. The present work describes the synthesis and characterization of these impurities.
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收藏
页码：3477 / 3489
页数：13
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