Synthesis and Characterization of Metabolites and Potential Impurities of Balsalazide Disodium, an Anti-Inflammatory Drug

被引：13

作者：

Khan, Md Umar ^{[2
]}

Baseer, M. A. ^{[2
]}

Kumar, S. Ranjith

Saravanakumar, M.

Prasannanjali, A. G.

Gupta, P. Badarinadh

Kaushik, Vipin K.

Handa, Vijay K.

Islam, Aminul ^{[1
]}

机构：

[1] Aurobindo Pharma Ltd, APL Res Ctr, Chem Res & Dev Dept, Chem R&D, Hyderabad 500072, Andhra Pradesh, India

[2] Yeshwant Mahavidyalaya, Organ Chem Res Lab, Nanded, India

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 15期

关键词：

5-Aminosalicylic acid; balsalazide; diazo coupling; impurities; synthesis; 5-AMINOSALICYLIC ACID ENEMAS; ULCERATIVE-COLITIS; SULFASALAZINE; MESALAZINE; DISEASE;

D O I：

10.1080/00397910903221068

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Balsalazide disodium (Colazide (R)) is an oral prodrug of mesalamine (5-aminosalicylic acid) and possesses anti-inflammatory properties. During the process development for balsalazide disodium, we observed eight impurities, namely des--alanine balsalazide, balsalazide -alanine, balsalazide 3-isomer, decarboxy balsalazide, bis-azo salicylic acid, biphenyl-azo salicylic acid, bis-azo diacid, and bis-azo triacid. The present work describes the synthesis and characterization of these impurities.

引用

页码：2241 / 2253

页数：13

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