Polypodiside Attenuates Inflammation Induced by High Glucose in Mesangial Cells via MAPK/NF-xB Pathway

被引：0
|
作者：
Li, Yan [1 ,2 ]
Zhou, Zheren [3 ,4 ]
Xia, Yuan [3 ]
Zhang, Xinyi [3 ]
Ye, Zixin [3 ]
Zhang, Yuhan [3 ]
Yang, Feng [3 ,4 ]
Yao, Huankai [1 ,2 ]
机构：
[1] Xuzhou Med Univ, Sch Pharm, Xuzhou 221004, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, Sch Stomatol, Xuzhou 221004, Jiangsu, Peoples R China
[4] Xuzhou Med Univ, Affliated Hosp, Dept Stomatol, Xuzhou 221006, Jiangsu, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2022年 / 41卷 / 07期
关键词：
inflammatio; MAPK; mesangial cell; NF-xB; polypodiside; NF-KAPPA-B; PATHOGENESIS; MOLECULES;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. Inflammation plays a crucial role in the pathogenesis of DN. As a natural Nrf2 activator, polypodiside has showed the potential to attenuate DN in vitro. To further uncover its anti-inflamamtory effects, we have employed mesangial cells cultured in high glucose. The results showed polypodiside reduced the pro-inflammatory cytokines which were activated by high glucose. Then the exploration revealed polypodiside inhibited MAPK/NF-xB pathway to attenuate inflammation. And the anti-inflammatory effects of polypodiside was closely associated with the activation of Nrf2. These results can give more evidences to understand the protective effects of polypodiside against DN and its application in practice.
引用
收藏
页码：1433 / 1439
页数：7
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