Polypodiside Attenuates Inflammation Induced by High Glucose in Mesangial Cells via MAPK/NF-xB Pathway

被引：0
|
作者：
Li, Yan [1 ,2 ]
Zhou, Zheren [3 ,4 ]
Xia, Yuan [3 ]
Zhang, Xinyi [3 ]
Ye, Zixin [3 ]
Zhang, Yuhan [3 ]
Yang, Feng [3 ,4 ]
Yao, Huankai [1 ,2 ]
机构：
[1] Xuzhou Med Univ, Sch Pharm, Xuzhou 221004, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, Sch Stomatol, Xuzhou 221004, Jiangsu, Peoples R China
[4] Xuzhou Med Univ, Affliated Hosp, Dept Stomatol, Xuzhou 221006, Jiangsu, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2022年 / 41卷 / 07期
关键词：
inflammatio; MAPK; mesangial cell; NF-xB; polypodiside; NF-KAPPA-B; PATHOGENESIS; MOLECULES;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. Inflammation plays a crucial role in the pathogenesis of DN. As a natural Nrf2 activator, polypodiside has showed the potential to attenuate DN in vitro. To further uncover its anti-inflamamtory effects, we have employed mesangial cells cultured in high glucose. The results showed polypodiside reduced the pro-inflammatory cytokines which were activated by high glucose. Then the exploration revealed polypodiside inhibited MAPK/NF-xB pathway to attenuate inflammation. And the anti-inflammatory effects of polypodiside was closely associated with the activation of Nrf2. These results can give more evidences to understand the protective effects of polypodiside against DN and its application in practice.
引用
收藏
页码：1433 / 1439
页数：7
相关论文
共 50 条
  • [31] Isonardosinone attenuates osteoclastogenesis and OVX-induced bone loss via the MAPK/NF-κB pathway
    Wen, Guangwei
    Li, Haishan
    Yang, Jiasheng
    Mai, Bin
    Zhou, Tengpeng
    Mo, Guoye
    Li, Yongxian
    Lai, Yiyi
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2025, 497
  • [32] Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway
    Chen Chen
    Yan Shi
    Jiulong Ma
    Zhen Chen
    Ming Zhang
    Yan Zhao
    Diabetology & Metabolic Syndrome, 14
  • [33] Thalidomide decreases high glucose-induced extracellular matrix protein synthesis in mesangial cells via the AMPK pathway
    Zhang, Hong-Xia
    Yuan, Jie
    Li, Ya-Feng
    Li, Rong-Shan
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 17 (01) : 927 - 934
  • [34] Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway
    Chen, Chen
    Shi, Yan
    Ma, Jiulong
    Chen, Zhen
    Zhang, Ming
    Zhao, Yan
    DIABETOLOGY & METABOLIC SYNDROME, 2022, 14 (01):
  • [35] Isoliquiritigenin attenuates high glucose-induced proliferation, inflammation, and extracellular matrix deposition in glomerular mesangial cells by suppressing JAK2/STAT3 pathway
    Ziyuan Zhang
    Shufen Deng
    Qiwen Shi
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, 397 : 123 - 131
  • [36] Isoliquiritigenin attenuates high glucose-induced proliferation, inflammation, and extracellular matrix deposition in glomerular mesangial cells by suppressing JAK2/STAT3 pathway
    Zhang, Ziyuan
    Deng, Shufen
    Shi, Qiwen
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2024, 397 (01) : 123 - 131
  • [37] Prunella vulgaris attenuates diabetic renal injury by suppressing high glucose-induced mesangial fibrosis and inflammation
    Namgung, Seung
    Yoon, Jung Joo
    Han, Byung Hyuk Han
    Choi, Eun Sik
    Hong, Mi Hyeon
    Lee, Yun Jung
    Kang, Dae Gill
    Lee, Ho Sub
    FASEB JOURNAL, 2017, 31
  • [38] Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway
    Wilmer, WA
    Dixon, CL
    Hebert, C
    KIDNEY INTERNATIONAL, 2001, 60 (03) : 858 - 871
  • [39] Isorhamnetin attenuates TNF-α-induced inflammation, proliferation, and migration in human bronchial epithelial cells via MAPK and NF-κB pathways
    Ren, Xiaojie
    Han, Longyin
    Li, Yongxing
    Zhao, Huanyi
    Zhang, Ziyin
    Zhuang, Yuerong
    Zhong, Ming
    Wang, Qiang
    Ma, Wuhua
    Wang, Yong
    ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 2021, 304 (04): : 901 - 913
  • [40] Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF-κB/MAPK signaling pathway
    Chu, Chu
    Ru, Huan
    Chen, Yuyan
    Xu, Jinhua
    Wang, Caihong
    Jin, Yuanxiang
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2024, 56 (06): : 905 - 915
12345