Vascular endothelial growth factor isoforms 121 and 165 are expressed on B-chronic lymphocytic leukemia cells

被引：0
|
作者：
Molica, S
Santoro, R
Digiesi, G
Dattilo, A
Levato, D
Muleo, G
机构：
[1] Azienda Osped Pugliese Ciaccio, Ctr Emostasi & Trombosi, I-88100 Catanzaro, Italy
[2] Azienda Osped Pugliese Ciaccio, Div Ematol & Oncol Clin, I-88100 Catanzaro, Italy
[3] IRCCS, Ist Regina Elena, Serv Patol Clin, Rome, Italy
来源：
HAEMATOLOGICA | 2000年 / 85卷 / 10期
关键词：
chronic lymphocytic leukemia; VEGF-expression; disease-progression;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We used flow cytometry to analyze the expression of vascular endothelial growth factor (VEGF) on leukemic cells of 11 B-CLL patients using a monoclonal antibody directed against the 121 and 165 isoforms. All patients tested displayed a positive reaction for VEGF. Interestingly, mean fluorescence intensity (MFI) of cases with a progressive pattern of disease was higher than MFI of patients with stable disease. Cellular VEGF-expression may be involved in disease progression.
引用
收藏
页码：1106 / 1108
页数：3
相关论文
共 50 条
  • [41] Lymphotoxin-α is an autocrine growth factor for chronic lymphocytic leukemia B cells
    Kulmburg, P
    Radke, M
    Digel, W
    LEUKEMIA, 1998, 12 (04) : 493 - 498
  • [42] Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage
    Enomoto, H
    Inoki, I
    Komiya, K
    Shiomi, T
    Ikeda, E
    Obata, K
    Matsumoto, H
    Toyama, Y
    Okada, Y
    AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (01): : 171 - 181
  • [43] Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer
    Makoto Tayama
    Tomohisa Furuhata
    Yoshiko Inafuku
    Kenji Okita
    Toshihiko Nishidate
    Toru Mizuguchi
    Yasutoshi Kimura
    Koichi Hirata
    World Journal of Gastroenterology, 2011, 17 (44) : 4867 - 4874
  • [44] Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer
    Tayama, Makoto
    Furuhata, Tomohisa
    Inafuku, Yoshiko
    Okita, Kenji
    Nishidate, Toshihiko
    Mizuguchi, Toru
    Kimura, Yasutoshi
    Hirata, Koichi
    WORLD JOURNAL OF GASTROENTEROLOGY, 2011, 17 (44) : 4867 - 4874
  • [45] Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF(121) and VEGF(165) but not VEGF(189)
    Cheng, SY
    Nagane, M
    Huang, HJS
    Cavenee, WK
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) : 12081 - 12087
  • [46] Circulating vascular endothelial growth factor (VEGF) and its soluble receptors in patients with chronic lymphocytic leukemia
    Gora-Tybor, J
    Blonski, JZ
    Robak, T
    EUROPEAN CYTOKINE NETWORK, 2005, 16 (01) : 41 - 46
  • [47] B-CHRONIC LYMPHOCYTIC-LEUKEMIA IN LATVIA - EPIDEMIOLOGIC ASPECTS
    YAVORKOVSKY, LI
    TEREBKOVA, ZF
    NIKULSHIN, SV
    YAVORKOVSKY, LL
    EUROPEAN JOURNAL OF HAEMATOLOGY, 1993, 51 (04) : 214 - 217
  • [48] THE NATURE OF THE B-LYMPHOCYTE IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA
    CALIGARISCAPPIO, F
    GOTTARDI, D
    ALFARANO, A
    STACCHINI, A
    GREGORETTI, MG
    GHIA, P
    BERTERO, MT
    NOVARINO, A
    BERGUI, L
    BLOOD CELLS, 1993, 19 (03): : 601 - 613
  • [49] Cyclosporin A and dexamethasone induce apoptosis in malignant cells of patients with B-chronic lymphocytic leukemia
    Trentin, L.
    Cabrelle, A.
    Maschio, N.
    Carraro, S.
    Bonanni, L.
    Gattazzo, C.
    Biasiolo, G.
    Frezzato, F.
    Adami, F.
    Agostini, C.
    Miorin, M.
    Zambello, R.
    Pandolfi, F.
    Semenzato, G.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 487 - 487
  • [50] Vascular endothelial growth factor B, a novel growth factor for endothelial cells
    Olofsson, B
    Pajusola, K
    Kaipainen, A
    vonEuler, G
    Joukov, V
    Saksela, O
    Orpana, A
    Petersson, RF
    Alitalo, K
    Eriksson, U
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) : 2576 - 2581
12345