Vascular endothelial growth factor isoforms 121 and 165 are expressed on B-chronic lymphocytic leukemia cells

被引：0
|
作者：
Molica, S
Santoro, R
Digiesi, G
Dattilo, A
Levato, D
Muleo, G
机构：
[1] Azienda Osped Pugliese Ciaccio, Ctr Emostasi & Trombosi, I-88100 Catanzaro, Italy
[2] Azienda Osped Pugliese Ciaccio, Div Ematol & Oncol Clin, I-88100 Catanzaro, Italy
[3] IRCCS, Ist Regina Elena, Serv Patol Clin, Rome, Italy
来源：
HAEMATOLOGICA | 2000年 / 85卷 / 10期
关键词：
chronic lymphocytic leukemia; VEGF-expression; disease-progression;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We used flow cytometry to analyze the expression of vascular endothelial growth factor (VEGF) on leukemic cells of 11 B-CLL patients using a monoclonal antibody directed against the 121 and 165 isoforms. All patients tested displayed a positive reaction for VEGF. Interestingly, mean fluorescence intensity (MFI) of cases with a progressive pattern of disease was higher than MFI of patients with stable disease. Cellular VEGF-expression may be involved in disease progression.
引用
收藏
页码：1106 / 1108
页数：3
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