Cu(OTf)2/Cu-catalyzed four-component reaction: a facile synthesis of α-alkoxytriazoles via click chemistry

被引：21
|
作者：
Yadav, J. S. [1 ]
Reddy, B. V. Subba [1 ]
Reddy, G. Madhusudhan [1 ]
Anjum, S. Rehana [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 44期
关键词：
Click reactions; Hemi-acetal formation; Azidation; alpha-Alkoxytriazoles; ONE-POT PROCEDURE; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; TERMINAL ALKYNES; CYCLOADDITIONS; DENDRIMERS; EFFICIENCY; LIGATION; LIBRARY; AZIDES; DNA;
D O I：
10.1016/j.tetlet.2009.08.027
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aldehyde, alcohol, azide, and alkyne undergo smooth coupling by means of acetal formation, azidation, and a Subsequent 'click reaction' in the presence of copper(II) triflate and copper metal in acetonitrile to furnish alpha-alkoxy-1,2,3-triazoles in good yields. The method provides a convenient route to prepare a wide range of triazoles in a one-pot operation via a four-component reaction. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6029 / 6031
页数：3
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