SYNTHESIS AND BIOLOGICAL EVALUATION OF TRIAZOLYL MONASTROL ANALOGUES USING Cu-CATALYZED CLICK CHEMISTRY

被引：5

作者：

Hassan, Hani Mutlak A. ^{[1
]}

Denetiu, Iuliana ^{[1
]}

Sakkaf, Kaltoom ^{[1
]}

Khan, Khalid A. ^{[2
]}

Pushparaj, Peter N. ^{[3
]}

Gauthaman, Kalamegam ^{[3
]}

机构：

[1] King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia

[2] King Abdulaziz Univ, Fac Sci, Dept Chem, POB 80203, Jeddah 21589, Saudi Arabia

[3] King Abdulaziz Univ, Ctr Excellence Genom Med Res, POB 80216, Jeddah 21589, Saudi Arabia

来源：

HETEROCYCLES | 2017年 / 94卷 / 10期

关键词：

Monastrol Analogue; Click Chemistry; Cu-Catalysis; Triazole; Anticancer Activity; MITOTIC KINESIN EG5; SOLVENT-FREE; BIGINELLI REACTION; TERMINAL ALKYNES; IN-SITU; INHIBITORS; DIHYDROPYRIMIDINE; DISCOVERY; CYCLOADDITIONS; AZIDES;

D O I：

10.3987/COM-17-13766

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of triazolyl monastrol analogues through a Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition (CuAAC) reactions and their biological evaluation against cancer cell lines is described.

引用

页码：1856 / 1869

页数：14

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