SYNTHESIS AND BIOLOGICAL EVALUATION OF TRIAZOLYL MONASTROL ANALOGUES USING Cu-CATALYZED CLICK CHEMISTRY

被引：5
|
作者：
Hassan, Hani Mutlak A. [1 ]
Denetiu, Iuliana [1 ]
Sakkaf, Kaltoom [1 ]
Khan, Khalid A. [2 ]
Pushparaj, Peter N. [3 ]
Gauthaman, Kalamegam [3 ]
机构：
[1] King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia
[2] King Abdulaziz Univ, Fac Sci, Dept Chem, POB 80203, Jeddah 21589, Saudi Arabia
[3] King Abdulaziz Univ, Ctr Excellence Genom Med Res, POB 80216, Jeddah 21589, Saudi Arabia
来源：
HETEROCYCLES | 2017年 / 94卷 / 10期
关键词：
Monastrol Analogue; Click Chemistry; Cu-Catalysis; Triazole; Anticancer Activity; MITOTIC KINESIN EG5; SOLVENT-FREE; BIGINELLI REACTION; TERMINAL ALKYNES; IN-SITU; INHIBITORS; DIHYDROPYRIMIDINE; DISCOVERY; CYCLOADDITIONS; AZIDES;
D O I：
10.3987/COM-17-13766
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of triazolyl monastrol analogues through a Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition (CuAAC) reactions and their biological evaluation against cancer cell lines is described.
引用
收藏
页码：1856 / 1869
页数：14
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