Cu(OTf)2/Cu-catalyzed four-component reaction: a facile synthesis of α-alkoxytriazoles via click chemistry

被引：21

作者：

Yadav, J. S. ^{[1
]}

Reddy, B. V. Subba ^{[1
]}

Reddy, G. Madhusudhan ^{[1
]}

Anjum, S. Rehana ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 44期

关键词：

Click reactions; Hemi-acetal formation; Azidation; alpha-Alkoxytriazoles; ONE-POT PROCEDURE; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; TERMINAL ALKYNES; CYCLOADDITIONS; DENDRIMERS; EFFICIENCY; LIGATION; LIBRARY; AZIDES; DNA;

D O I：

10.1016/j.tetlet.2009.08.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldehyde, alcohol, azide, and alkyne undergo smooth coupling by means of acetal formation, azidation, and a Subsequent 'click reaction' in the presence of copper(II) triflate and copper metal in acetonitrile to furnish alpha-alkoxy-1,2,3-triazoles in good yields. The method provides a convenient route to prepare a wide range of triazoles in a one-pot operation via a four-component reaction. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6029 / 6031

页数：3

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