Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process

被引：76

作者：

Furuta, Takumi ^{[1
]}

Kitamura, Yuki ^{[1
]}

Hashimoto, Ayano ^{[1
]}

Fujii, Satoshi ^{[1
]}

Tanaka, Kiyoshi ^{[1
]}

Kan, Toshiyuki ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 02期

关键词：

D O I：

10.1021/ol062599z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the domino process, which includes aryl-aryl coupling and C-N bond formations concomitant with a deamidation reaction. The versatility and applicability to a broad range of substrates make this reaction useful for the development of bioactive derivatives.

引用

页码：183 / 186

页数：4

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