Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process

被引：76
|
作者：
Furuta, Takumi [1 ]
Kitamura, Yuki [1 ]
Hashimoto, Ayano [1 ]
Fujii, Satoshi [1 ]
Tanaka, Kiyoshi [1 ]
Kan, Toshiyuki [1 ]
机构：
[1] Univ Shizuoka, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 02期
关键词：
D O I：
10.1021/ol062599z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the domino process, which includes aryl-aryl coupling and C-N bond formations concomitant with a deamidation reaction. The versatility and applicability to a broad range of substrates make this reaction useful for the development of bioactive derivatives.
引用
收藏
页码：183 / 186
页数：4
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