The domestication of Cas9

被引：10
|
作者：
Urnov, Fyodor [1 ]
机构：
[1] Sangamo BioSci, Richmond, CA 94804 USA
来源：
NATURE | 2016年 / 529卷 / 7587期
关键词：
GENOME; NUCLEASES;
D O I：
10.1038/529468a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The enzyme Cas9 is used in genome editing to cut selected DNA sequences, but it also creates breaks at off-target sites. Protein engineering has now been used to make Cas9 enzymes that have minimal off-target effects. See Article p.490
引用
收藏
页码：468 / 469
页数：2
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