Short and effective synthesis of a thiophene analogue of (±)-4-lpomeanol and its biological evaluation

被引：0

作者：

Krauss, Juergen ^{[1
]}

Unterreitmeier, Doris ^{[1
]}

Bracher, Franz ^{[1
]}

机构：

[1] Univ Munich, Dept Pharm, D-81377 Munich, Germany

来源：

TURKISH JOURNAL OF CHEMISTRY | 2006年 / 30卷 / 04期

关键词：

Sonogashira reaction; 4-ipomeanol; cytotoxic activity; MTT assay;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The thiophene analogue of (+/-)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol. The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisation of the triple bond. The resulting thiophene was tested in the MTT assay for its cytotoxic activity against HL 60 cells.

引用

页码：451 / 454

页数：4

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