Short and effective synthesis of a thiophene analogue of (±)-4-lpomeanol and its biological evaluation

被引：0
|
作者：
Krauss, Juergen [1 ]
Unterreitmeier, Doris [1 ]
Bracher, Franz [1 ]
机构：
[1] Univ Munich, Dept Pharm, D-81377 Munich, Germany
来源：
TURKISH JOURNAL OF CHEMISTRY | 2006年 / 30卷 / 04期
关键词：
Sonogashira reaction; 4-ipomeanol; cytotoxic activity; MTT assay;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The thiophene analogue of (+/-)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol. The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisation of the triple bond. The resulting thiophene was tested in the MTT assay for its cytotoxic activity against HL 60 cells.
引用
收藏
页码：451 / 454
页数：4
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