Development of a hybrid scaffold and a bioreactor for cartilage regeneration

被引：4

作者：

Lee, Seung-Jae ^{[2
]}

Lee, In Hwan ^{[1
]}

Park, Jeong Hun ^{[1
]}

Gwak, So-Jung ^{[3
]}

Rhie, Jong-Won ^{[4
]}

Cho, Dong-Woo ^{[5
]}

Ko, Tae Jo ^{[6
]}

Kim, Dong Sung ^{[7
]}

机构：

[1] Chungbuk Natl Univ, Sch Mech Engn, Cheongju 361763, South Korea

[2] Chungnam Natl Univ, Mechatron Grp BK21, Taejon 305764, South Korea

[3] CKD Pharmaceut Corp, DDS Res Lab, CKD Res Inst, Cheonan 330831, South Korea

[4] Catholic Univ, Dept Plast Surg, Coll Med, Seoul 137701, South Korea

[5] Pohang Univ Sci & Technol, Dept Mech Engn, Pohang 790784, South Korea

[6] Yeungnam Univ, Sch Mech Engn, Kyongsan 712749, South Korea

[7] Chung Ang Univ, Sch Mech Engn, Seoul 156756, South Korea

来源：

CHINESE SCIENCE BULLETIN | 2009年 / 54卷 / 19期

关键词：

cartilage; scaffold; bioreactor; alginate; agarose; CARBONATE-BASED PREPOLYMERS;

D O I：

10.1007/s11434-009-0602-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We developed a hybrid scaffold and a bioreactor for cartilage regeneration. The hybrid scaffold was developed as combination of two components: a biodegradable framework and hydrogel-containing chondrocytes. We performed the MTT cell proliferation assay to compare the proliferation and viability of chondrocytes on three types of scaffolds: an alginate gel, the hybrid scaffold, and an alginate sponge. Cells were encapsulated in 2% agarose gel. The bioreactor consisted of a circulation system and a compression system. We performed dynamic cell culture on these agarose gels in the bioreactor for 3 days.

引用

页码：3608 / 3612

页数：5

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