Development of a hybrid scaffold and a bioreactor for cartilage regeneration

被引：4

作者：

Lee, Seung-Jae ^{[2
]}

Lee, In Hwan ^{[1
]}

Park, Jeong Hun ^{[1
]}

Gwak, So-Jung ^{[3
]}

Rhie, Jong-Won ^{[4
]}

Cho, Dong-Woo ^{[5
]}

Ko, Tae Jo ^{[6
]}

Kim, Dong Sung ^{[7
]}

机构：

[1] Chungbuk Natl Univ, Sch Mech Engn, Cheongju 361763, South Korea

[2] Chungnam Natl Univ, Mechatron Grp BK21, Taejon 305764, South Korea

[3] CKD Pharmaceut Corp, DDS Res Lab, CKD Res Inst, Cheonan 330831, South Korea

[4] Catholic Univ, Dept Plast Surg, Coll Med, Seoul 137701, South Korea

[5] Pohang Univ Sci & Technol, Dept Mech Engn, Pohang 790784, South Korea

[6] Yeungnam Univ, Sch Mech Engn, Kyongsan 712749, South Korea

[7] Chung Ang Univ, Sch Mech Engn, Seoul 156756, South Korea

来源：

CHINESE SCIENCE BULLETIN | 2009年 / 54卷 / 19期

关键词：

cartilage; scaffold; bioreactor; alginate; agarose; CARBONATE-BASED PREPOLYMERS;

D O I：

10.1007/s11434-009-0602-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We developed a hybrid scaffold and a bioreactor for cartilage regeneration. The hybrid scaffold was developed as combination of two components: a biodegradable framework and hydrogel-containing chondrocytes. We performed the MTT cell proliferation assay to compare the proliferation and viability of chondrocytes on three types of scaffolds: an alginate gel, the hybrid scaffold, and an alginate sponge. Cells were encapsulated in 2% agarose gel. The bioreactor consisted of a circulation system and a compression system. We performed dynamic cell culture on these agarose gels in the bioreactor for 3 days.

引用

页码：3608 / 3612

页数：5

共 50 条

[31] Biofabrication of an in situ hypoxia-delivery scaffold for cartilage regeneration
Di Gesu, R.
Piccionello, A. Palumbo
Vitale, G.
Buscemi, S.
Panzavolta, S.
Di Filippo, M. F.
Leonarda, A.
Cuccia, M.
Di Prima, A.
Gottardi, R.
BIOFABRICATION, 2025, 17 (02)
[32] Cartilage-like microfiber/hydrogel composite scaffold for articular cartilage therapy and regeneration
Jeong, Young Hun
Park, Cheol Woo
Kim, Gyu Man
Kwak, Moon Kyu
JOURNAL OF BONE AND MINERAL RESEARCH, 2018, 33 : 239 - 239
[33] Cartilage Extracellular Matrix Scaffold With Kartogenin-Encapsulated PLGA Microspheres for Cartilage Regeneration
Zhao, Yanhong
Zhao, Xige
Zhang, Rui
Huang, Ying
Li, Yunjie
Shan, Minhui
Zhong, Xintong
Xing, Yi
Wang, Min
Zhang, Yang
Zhao, Yanmei
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 8 (08):
[34] In vivo cartilage regeneration in a multi-layered articular cartilage architecture mimicking scaffold
Rajagopal, K.
Ramesh, S.
Walter, N. M.
Arora, A.
Katti, D. S.
Madhuri, V
BONE & JOINT RESEARCH, 2020, 9 (09): : 601 - 612
[35] Cell and Biomimetic Scaffold-Based Approaches for Cartilage Regeneration
Sun, Aaron X.
Numpaisal, Piya-on
Gottardi, Riccardo
Shen, He
Yang, Guang
Tuan, Rocky S.
OPERATIVE TECHNIQUES IN ORTHOPAEDICS, 2016, 26 (03) : 135 - 146
[36] An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
Vikingsson, L.
Gomez-Tejedor, J. A.
Gallego Ferrer, G.
Gomez Ribelles, J. L.
JOURNAL OF BIOMECHANICS, 2015, 48 (07) : 1310 - 1317
[37] Curcumin Loaded Gellan Gum Hydrogel Scaffold For Cartilage Regeneration
Khang, G.
Jeon, Y.
Kim, D.
Sim, B.
Song, J.
Tripathy, N.
TISSUE ENGINEERING PART A, 2016, 22 : S124 - S124
[38] KARTOGENIN LOADED PHOTO-CROSSLINKABLE SCAFFOLD FOR CARTILAGE REGENERATION
Shi, D.
Xu, X.
Jiang, Q.
OSTEOARTHRITIS AND CARTILAGE, 2015, 23 : A141 - A141
[39] Effect of the scaffold in maintenance of suitable chondrcyte morphology in cartilage regeneration
Rodriguez, J.
Rubiralta, X.
Farre, J.
Fabregues, P. J.
Aguilera, J. M.
Barrachina, J.
Granell, F.
Nebot, J.
Cairo, J. J.
Godia, F.
CELL TECHNOLOGY FOR CELL PRODUCTS, 2007, : 147 - +
[40] Preparation and Characterization of Injectable Biohybrid Thermogel Scaffold for Cartilage Regeneration
Kim, Seong Eun
Shim, Hye-Eun
Kang, Sun-Woong
Huh, Kang Moo
POLYMER-KOREA, 2024, 48 (05) : 518 - 529

← 1 2 3 4 5 →