Effects of peripheral 5-HT2 and 5-HT3 receptor agonists on food intake in food-deprived and 2-deoxy-D-glucose-treated rats

被引：19
|
作者：
Sugimoto, Y
Yamada, J
Yoshikawa, T
Noma, T
Horisaka, K
机构：
[1] Department of Pharmacology, Kobe Pharmaceutical University, Kobe 658, Motoyamakita-machi, Higashinada-ku
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 316卷 / 01期
关键词：
alpha-methyl-5-HT (alpha-methyl-5-hydroxytryptamine); 2-methyl-5-HT (2-methyl-5-hydroxytryptamine); food intake; 2-deoxy-D-glucose; 5-HT2A receptor; peripheral; 5-HT3; receptor;
D O I：
10.1016/S0014-2999(96)00660-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Peripherally administered, the 5-HT2 receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-HT), significantly suppressed the food intake of food-deprived rats. alpha-Methyl-5-HT also inhibited 2-deoxy-D-glucose-induced hyperphagia in rats. The alpha-methyl-5-HT-induced hypophagia was antagonized by the 5-HT2A receptor antagonist, ketanserin. The alpha-methyl-5-HT-induced decrease in food intake of food-deprived rats was not inhibited by prior adrenodemedullation. The peripheral 5-HT3 receptor agonist, 2-methyl-5-HT, did not affect food intake in food-deprived or 2-deoxy-D-glucose-treated rats. These results suggest that the peripheral 5-HT2A receptor may participate in the regulation of food intake and that its hypophagic effects are not associated with its adrenaline-releasing effects from the adrenal gland. Lastly, the peripheral 5-HT3 receptor did not participate in feeding control.
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页码：15 / 21
页数：7
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