Effects of peripheral 5-HT2 and 5-HT3 receptor agonists on food intake in food-deprived and 2-deoxy-D-glucose-treated rats

被引：19

作者：

Sugimoto, Y

Yamada, J

Yoshikawa, T

Noma, T

Horisaka, K

机构：

[1] Department of Pharmacology, Kobe Pharmaceutical University, Kobe 658, Motoyamakita-machi, Higashinada-ku

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 316卷 / 01期

关键词：

alpha-methyl-5-HT (alpha-methyl-5-hydroxytryptamine); 2-methyl-5-HT (2-methyl-5-hydroxytryptamine); food intake; 2-deoxy-D-glucose; 5-HT2A receptor; peripheral; 5-HT3; receptor;

D O I：

10.1016/S0014-2999(96)00660-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Peripherally administered, the 5-HT2 receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-HT), significantly suppressed the food intake of food-deprived rats. alpha-Methyl-5-HT also inhibited 2-deoxy-D-glucose-induced hyperphagia in rats. The alpha-methyl-5-HT-induced hypophagia was antagonized by the 5-HT2A receptor antagonist, ketanserin. The alpha-methyl-5-HT-induced decrease in food intake of food-deprived rats was not inhibited by prior adrenodemedullation. The peripheral 5-HT3 receptor agonist, 2-methyl-5-HT, did not affect food intake in food-deprived or 2-deoxy-D-glucose-treated rats. These results suggest that the peripheral 5-HT2A receptor may participate in the regulation of food intake and that its hypophagic effects are not associated with its adrenaline-releasing effects from the adrenal gland. Lastly, the peripheral 5-HT3 receptor did not participate in feeding control.

引用

页码：15 / 21

页数：7

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