Hydrogen peroxide mediated formation of heteroaryl ethers from pyridotriazol-1-yloxy heterocycles and arylboronic acids

被引：2
|
作者：
Bardhan, Sujata [1 ]
Tabei, Keiko [1 ]
Wan, Zhao-Kui [2 ]
Mansour, Tarek S. [1 ]
机构：
[1] Wyeth Res, Chem Sci, Pearl River, NY 10965 USA
[2] Wyeth Res, Chem Sci, Cambridge, MA 02140 USA
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 41期
关键词：
OXIDATIVE PALLADIUM CATALYSIS; BORONIC ACIDS; MOLECULAR-OXYGEN; DIRECT ARYLATION; SNAR REACTIONS; BASE-FREE; PHENOLS; DERIVATIVES; ACTIVATION; CONVERSION;
D O I：
10.1016/j.tetlet.2009.07.135
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pyridotriazol-1-yloxypyrimidine 3 reacts with arylboronic acids under palladium-free, Cs2CO3, (0.8%) H2O2, and DME conditions to produce heteroaryl ethers 4-16 in good yields comparable to the oxidative palladium-catalyzed reaction. The yields of aryl ethers 17-19 from quinazoline 2 with (0.8%) H2O2 were modest. Hydrogen peroxide is Superior to dioxygen as an oxidant in these reactions. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5733 / 5736
页数：4
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