Hydrogen peroxide mediated formation of heteroaryl ethers from pyridotriazol-1-yloxy heterocycles and arylboronic acids

被引：2

作者：

Bardhan, Sujata ^{[1
]}

Tabei, Keiko ^{[1
]}

Wan, Zhao-Kui ^{[2
]}

Mansour, Tarek S. ^{[1
]}

机构：

[1] Wyeth Res, Chem Sci, Pearl River, NY 10965 USA

[2] Wyeth Res, Chem Sci, Cambridge, MA 02140 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 41期

关键词：

OXIDATIVE PALLADIUM CATALYSIS; BORONIC ACIDS; MOLECULAR-OXYGEN; DIRECT ARYLATION; SNAR REACTIONS; BASE-FREE; PHENOLS; DERIVATIVES; ACTIVATION; CONVERSION;

D O I：

10.1016/j.tetlet.2009.07.135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyridotriazol-1-yloxypyrimidine 3 reacts with arylboronic acids under palladium-free, Cs2CO3, (0.8%) H2O2, and DME conditions to produce heteroaryl ethers 4-16 in good yields comparable to the oxidative palladium-catalyzed reaction. The yields of aryl ethers 17-19 from quinazoline 2 with (0.8%) H2O2 were modest. Hydrogen peroxide is Superior to dioxygen as an oxidant in these reactions. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5733 / 5736

页数：4

共 40 条

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