Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

被引：0
|
作者：
Sahin, Sinem [1 ]
Mesut, Burcu [2 ]
Durgun, M. Ezgi [2 ]
Ozcelik, Esher [3 ]
Ozsoy, Yildiz [2 ]
机构：
[1] Onko Kocsel Pharmaceut, Kocaeli, Turkey
[2] Istanbul Univ, Fac Pharm, Pharmaceut Technol Dept, Istanbul, Turkey
[3] Cibali Hlth & Social Secur Ctr, Istanbul, Turkey
来源：
ISTANBUL JOURNAL OF PHARMACY | 2021年 / 51卷 / 01期
关键词：
Fixed-Dose Tablet; Metformin; Repaglinide; TYPE-2; PHARMACOKINETICS; THERAPY; CARE;
D O I：
10.26650/IstanbulJPharm.2020.0070
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background and Aims: The study aimed to design a Fixed-dose tablet formulation of Metformine and Repaglinide. Methods: Wet granulation method was used to prepare tablet formulations. Characterization studies and dissolution studies were performed. Results: A stable formulation was developed according to the requirements of the pharmacopoeia criteria. This new formulsation dissolution results showed that Repaglinide and Metformin HCl dissolved more than 85% from film tablets at 15 minutes. Conclusion: Thus, an alternative product to the market product was developed.
引用
收藏
页码：26 / 34
页数：9
相关论文
共 50 条
  • [41] Fixed-dose combinations in type 2 diabetes - role of the canagliflozin metformin combination
    Fleming, Joshua W.
    Fleming, Laurie W.
    Davis, Courtney S.
    DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2015, 8 : 287 - 294
  • [42] Acarbose plus metformin fixed-dose combination in the management of type 2 diabetes
    Joshi, Shashank R.
    Ramachandran, Ambady
    Chadha, Manoj
    Chatterjee, Sudip
    Rathod, Rahul
    Kalra, Sanjay
    EXPERT OPINION ON PHARMACOTHERAPY, 2014, 15 (11) : 1611 - 1620
  • [43] Fixed-Dose Combination of Canagliflozin and Metformin for the Treatment of Type 2 Diabetes: An Overview
    Davidson, Jaime A.
    Sloan, Lance
    ADVANCES IN THERAPY, 2017, 34 (01) : 41 - 59
  • [44] Fixed-Dose Combination of Canagliflozin and Metformin for the Treatment of Type 2 Diabetes: An Overview
    Jaime A. Davidson
    Lance Sloan
    Advances in Therapy, 2017, 34 : 41 - 59
  • [45] Fixed-dose single tablet antidiabetic combinations
    Bailey, C. J.
    Day, C.
    DIABETES OBESITY & METABOLISM, 2009, 11 (06): : 527 - 533
  • [46] Designing of the fixed-dose gastroretentive bilayer tablet for sustained release of metformin and immediate release of atorvastatin
    Oh, Ju-Hee
    Lee, Ji Eun
    Kim, Yu Jeong
    Oh, Tack-Oon
    Han, SungKyun
    Jeon, Eun Kyung
    Shin, Kyungmin
    Kim, Dong-Hyun
    Hye Park, Chi
    Lee, Young-Joo
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2016, 42 (02) : 340 - 349
  • [47] A PHARMACOKINETIC COMPARISON BETWEEN FIXED-DOSE COMBINATION AND SEPARATE TABLETS OF ROSUVASTATIN AND METFORMIN IN FED STATE AND FOOD EFFECT OF FIXED-DOSE COMBINATION IN HEALTHY SUBJECTS.
    Kim, E.
    Rhee, S-J.
    Kim, Y.
    Oh, J.
    Suh, H.
    Lee, Y.
    Lee, Y.
    Cho, J-Y.
    Yu, K-S.
    Lee, H.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 103 : S40 - S40
  • [48] Pharmacokinetic Equivalence of the High Dose Strength Fixed-Dose Combination Tablet of Gemigliptin/Metformin Sustained Release (SR) and Individual Component Gemigliptin and Metformin XR Tablets in Healthy Subjects
    Cho, Yong-Soon
    Lee, Shi Hyang
    Lim, Hyeong-Seok
    Bae, Kyun-Seop
    JOURNAL OF KOREAN MEDICAL SCIENCE, 2018, 33 (41)
  • [49] Effects of pioglitazone in combination with metformin or a sulfonylurea compared to a fixed-dose combination of metformin and glibenclamide in patients with type 2 diabetes
    Comaschi, M.
    Demlcheli, A.
    Di Pietro, C.
    Bellatreccia, A.
    Mariz, S.
    DIABETES TECHNOLOGY & THERAPEUTICS, 2007, 9 (04) : 387 - 398
  • [50] Fixed combination of repaglinide and metformin in the management of type 2 diabetes
    Moses, Robert
    DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2009, 2 : 101 - 109
12345