Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

被引：0
|
作者：
Sahin, Sinem [1 ]
Mesut, Burcu [2 ]
Durgun, M. Ezgi [2 ]
Ozcelik, Esher [3 ]
Ozsoy, Yildiz [2 ]
机构：
[1] Onko Kocsel Pharmaceut, Kocaeli, Turkey
[2] Istanbul Univ, Fac Pharm, Pharmaceut Technol Dept, Istanbul, Turkey
[3] Cibali Hlth & Social Secur Ctr, Istanbul, Turkey
来源：
ISTANBUL JOURNAL OF PHARMACY | 2021年 / 51卷 / 01期
关键词：
Fixed-Dose Tablet; Metformin; Repaglinide; TYPE-2; PHARMACOKINETICS; THERAPY; CARE;
D O I：
10.26650/IstanbulJPharm.2020.0070
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background and Aims: The study aimed to design a Fixed-dose tablet formulation of Metformine and Repaglinide. Methods: Wet granulation method was used to prepare tablet formulations. Characterization studies and dissolution studies were performed. Results: A stable formulation was developed according to the requirements of the pharmacopoeia criteria. This new formulsation dissolution results showed that Repaglinide and Metformin HCl dissolved more than 85% from film tablets at 15 minutes. Conclusion: Thus, an alternative product to the market product was developed.
引用
收藏
页码：26 / 34
页数：9
相关论文
共 50 条
  • [31] Linagliptin fixed-dose combination with metformin is bioequivalent to free-pill combination therapy
    Buschke, Susanne
    Ring, Arne
    Friedrich, Christian
    Metzmann, Katrin
    Meinicke, Thomas
    PHARMACOTHERAPY, 2012, 32 (10): : E238 - E238
  • [32] Design of Experiments for Coating Process of Valsartan and Pravastatin Fixed-dose Combination Tablet
    Kim, Kangmin
    Kang, Jae Seon
    INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2017, 51 (01) : 128 - 135
  • [33] Enhanced Stability and Compatibility of Montelukast and Levocetirizine in a Fixed-Dose Combination Monolayer Tablet
    Yun, Tae Han
    Kim, Moon Jung
    Lee, Jung Gyun
    Bang, Kyu Ho
    Kim, Kyeong Soo
    PHARMACEUTICS, 2024, 16 (07)
  • [34] Bioequivalence of a Dolutegravir, Abacavir, and Lamivudine Fixed-Dose Combination Tablet and the Effect of Food
    Weller, Stephen
    Chen, Shuguang
    Borland, Julie
    Savina, Paul
    Wynne, Brian
    Piscitelli, Stephen C.
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2014, 66 (04) : 393 - 398
  • [35] FIXED-DOSE COMBINATION OF TRIMETHOPRIM
    WEISSMAN, JB
    NEW ENGLAND JOURNAL OF MEDICINE, 1974, 291 (25): : 1364 - 1365
  • [36] Apixaban and clopidogrel in a fixed-dose combination: Formulation and in vitro evaluation
    Al-Shami, Ni 'meh
    Naseef, Hani
    Kanaze, Feras
    SAUDI PHARMACEUTICAL JOURNAL, 2024, 32 (06)
  • [37] Empagliflozin/metformin fixed-dose combination: a review in patients with type 2 diabetes
    Hu, Jingbo
    Zou, Ping
    Zhang, Shuo
    Zhou, Minzhi
    Tan, Xueying
    EXPERT OPINION ON PHARMACOTHERAPY, 2016, 17 (18) : 2471 - 2477
  • [38] Determination of metformin in fixed-dose combination tablets by ATR-FTIR spectroscopy
    Sabbagh, B. A.
    Kumar, P. V.
    Chew, Y. L.
    Chin, J. H.
    Akowuah, G. A.
    CHEMICAL DATA COLLECTIONS, 2022, 39
  • [39] Fixed-dose combination of ertugliflozin and metformin hydrochloride for the treatment of type 2 diabetes
    Frias, Juan Pablo
    EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, 2019, 14 (02) : 75 - 83
  • [40] Effect of pioglitazone and metformin fixed-dose combination on glycaemic control in untreated patients
    Zhao, Z.
    Spanheimer, R.
    Perez, A.
    DIABETOLOGIA, 2009, 52 : S335 - S335
12345