Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

被引：0

作者：

Sahin, Sinem ^{[1
]}

Mesut, Burcu ^{[2
]}

Durgun, M. Ezgi ^{[2
]}

Ozcelik, Esher ^{[3
]}

Ozsoy, Yildiz ^{[2
]}

机构：

[1] Onko Kocsel Pharmaceut, Kocaeli, Turkey

[2] Istanbul Univ, Fac Pharm, Pharmaceut Technol Dept, Istanbul, Turkey

[3] Cibali Hlth & Social Secur Ctr, Istanbul, Turkey

来源：

ISTANBUL JOURNAL OF PHARMACY | 2021年 / 51卷 / 01期

关键词：

Fixed-Dose Tablet; Metformin; Repaglinide; TYPE-2; PHARMACOKINETICS; THERAPY; CARE;

D O I：

10.26650/IstanbulJPharm.2020.0070

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background and Aims: The study aimed to design a Fixed-dose tablet formulation of Metformine and Repaglinide. Methods: Wet granulation method was used to prepare tablet formulations. Characterization studies and dissolution studies were performed. Results: A stable formulation was developed according to the requirements of the pharmacopoeia criteria. This new formulsation dissolution results showed that Repaglinide and Metformin HCl dissolved more than 85% from film tablets at 15 minutes. Conclusion: Thus, an alternative product to the market product was developed.

引用

页码：26 / 34

页数：9

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