Brain perfusion in patients with severe sleep apnea syndrome (SAS) before and after n-CPAP-therapy

被引：0
|
作者：
Dannenberg, C [1 ]
Bosse-Henck, A [1 ]
Weiser, A [1 ]
Barthel, H [1 ]
Schedel, U [1 ]
Sattler, B [1 ]
Dietrich, J [1 ]
Knapp, WH [1 ]
Burchert, W [1 ]
机构：
[1] Univ Leipzig, Dept Nucl Med, Leipzig, Germany
来源：
RADIOACTIVE ISOTOPES IN CLINICAL MEDICINE AND RESEARCH XXIII | 1999年
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D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The aim of the study was to evaluate the therapeutic potential of nocturnal transnasal continuous positive airway pressure breathing (n-CPAP-therapy) with respect to regional cerebral blood flow. 30 patients with severe sleep apnea syndrome (SAS) underwent daytime Tc-99m-ECD SPET before and after 6 month n-CPAP-therapy and brain CT (n = 25) to evaluate atrophy SPET data were analysed visually by 3 experts: Perfusion deficits were mainly located in frontal and temporal lobes. Frontal (p < 0.01) and temporal (p < 0.05) activity significantly increased after therapy. In 10 patients with brain atrophy activity did not change significantly, what probably reflects morphological changes induced by hypoxemia and/or sleep fragmentation.
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页码：43 / 47
页数：5
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