Brain perfusion in patients with severe sleep apnea syndrome (SAS) before and after n-CPAP-therapy

被引：0

作者：

Dannenberg, C ^{[1
]}

Bosse-Henck, A ^{[1
]}

Weiser, A ^{[1
]}

Barthel, H ^{[1
]}

Schedel, U ^{[1
]}

Sattler, B ^{[1
]}

Dietrich, J ^{[1
]}

Knapp, WH ^{[1
]}

Burchert, W ^{[1
]}

机构：

[1] Univ Leipzig, Dept Nucl Med, Leipzig, Germany

来源：

RADIOACTIVE ISOTOPES IN CLINICAL MEDICINE AND RESEARCH XXIII | 1999年

关键词：

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The aim of the study was to evaluate the therapeutic potential of nocturnal transnasal continuous positive airway pressure breathing (n-CPAP-therapy) with respect to regional cerebral blood flow. 30 patients with severe sleep apnea syndrome (SAS) underwent daytime Tc-99m-ECD SPET before and after 6 month n-CPAP-therapy and brain CT (n = 25) to evaluate atrophy SPET data were analysed visually by 3 experts: Perfusion deficits were mainly located in frontal and temporal lobes. Frontal (p < 0.01) and temporal (p < 0.05) activity significantly increased after therapy. In 10 patients with brain atrophy activity did not change significantly, what probably reflects morphological changes induced by hypoxemia and/or sleep fragmentation.

引用

页码：43 / 47

页数：5

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