Highly enantioselective Ru-catalyzed asymmetric hydrogenation of β-keto ester in ionic liquid/methanol mixtures

被引：23

作者：

Oechsner, Eva ^{[1
]}

Schneiders, Karola ^{[1
]}

Junge, Kathrin ^{[2
]}

Beller, Matthias ^{[2
]}

Wasserscheid, Peter ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Chem & Bioengn, D-91058 Erlangen, Germany

[2] Univ Rostock, Leibniz Inst Catalysis, D-18059 Rostock, Germany

来源：

APPLIED CATALYSIS A-GENERAL | 2009年 / 364卷 / 1-2期

关键词：

Asymmetric catalysis; Hydrogenation; Ketones; Keto ester; Ionic liquid; CHIRAL MONODENTATE PHOSPHINES; RHODIUM COMPLEXES; CARBENE COMPLEXES; LIQUIDS; DEHYDROGENATION; ISOMERIZATION;

D O I：

10.1016/j.apcata.2009.05.020

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The enantioselective hydrogenation of methyl acetoacetate (MAA) was studied in detail using a ruthenium-monodentate binaphthophosphepine complex in a homogeneous solution formed by different ionic liquids and methanol. Remarkably, ionic liquid additives did not only open an attractive way for catalyst recycling in repetitive batch-mode but also led to significantly increased catalytic activity compared to pure methanol. Enantioselectivities up to 95% have been achieved in mixed ionic liquid/methanol systems which are comparable to the values obtained in pure methanol. (C) 2009 Published by Elsevier B.V.

引用

页码：8 / 14

页数：7

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