Highly enantioselective Ru-catalyzed asymmetric hydrogenation of β-keto ester in ionic liquid/methanol mixtures

被引:23
|
作者
Oechsner, Eva [1 ]
Schneiders, Karola [1 ]
Junge, Kathrin [2 ]
Beller, Matthias [2 ]
Wasserscheid, Peter [1 ]
机构
[1] Univ Erlangen Nurnberg, Dept Chem & Bioengn, D-91058 Erlangen, Germany
[2] Univ Rostock, Leibniz Inst Catalysis, D-18059 Rostock, Germany
关键词
Asymmetric catalysis; Hydrogenation; Ketones; Keto ester; Ionic liquid; CHIRAL MONODENTATE PHOSPHINES; RHODIUM COMPLEXES; CARBENE COMPLEXES; LIQUIDS; DEHYDROGENATION; ISOMERIZATION;
D O I
10.1016/j.apcata.2009.05.020
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The enantioselective hydrogenation of methyl acetoacetate (MAA) was studied in detail using a ruthenium-monodentate binaphthophosphepine complex in a homogeneous solution formed by different ionic liquids and methanol. Remarkably, ionic liquid additives did not only open an attractive way for catalyst recycling in repetitive batch-mode but also led to significantly increased catalytic activity compared to pure methanol. Enantioselectivities up to 95% have been achieved in mixed ionic liquid/methanol systems which are comparable to the values obtained in pure methanol. (C) 2009 Published by Elsevier B.V.
引用
收藏
页码:8 / 14
页数:7
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