A host-guest system based on collagen-like triple-helix hybridization

被引:6
|
作者
Delsuc, N. [1 ]
Uchinomiya, S. [2 ]
Ojida, A. [2 ]
Hamachi, I. [3 ]
机构
[1] UPMC Univ Paris 06, Sorbonne Univ, PSL Res Univ, Lab Biomol,Dept Chim,Ecole Normale Super,CNRS, 24 Rue Lhomond, F-75005 Paris, France
[2] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka, Japan
[3] Kyoto Univ, Grad Sch Engn, Dept Synthet Chem & Biol Chem, Kyoto, Japan
基金
日本学术振兴会;
关键词
DIKETOPIPERAZINE RECEPTORS; MOLECULAR RECOGNITION; MODEL; PEPTIDES; BINDING; PROBE; WATER; STABILIZATION; TRANSITION; STABILITY;
D O I
10.1039/c7cc03055j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A strategy inspired by tweezer receptors has been employed to develop a new host-guest system. The hybridization into a collagen-like triple helix is the driving force for the recognition that occurs with high affinity and selectivity. Several systems have been screened to find the best host-guest pair and this strategy may be implemented for tag fused protein recognition.
引用
收藏
页码:6856 / 6859
页数:4
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