N-Iodosuccinimide as a Precatalyst for Direct Cross-Coupling of Alcohols withC-Nucleophiles under Solvent-Free Reaction Conditions

被引：5

作者：

Ajvazi, Njomza ^{[1
]}

Stavber, Stojan ^{[1
,2
]}

机构：

[1] Jozef Stefan Int Postgrad Sch, Jamova 39, Ljubljana 1000, Slovenia

[2] Jozef Stefan Inst, Jamova 39, Ljubljana 1000, Slovenia

来源：

CATALYSTS | 2020年 / 10卷 / 08期

关键词：

alcohols; N-iodosuccinimide; C-C coupling; solvent-free reactions; green chemistry; SUBSTITUTION; ALKYLATION;

D O I：

10.3390/catal10080850

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

C-C bond formation is one of the most important implements in synthetic organic chemistry. In pursuit of effective synthetic routes functioning under greener pathways to achieve direct C-C bond formation, we reportN-iodosuccinimide (NIS) as the most effective precatalyst among theN-halosuccinimides (NXSs) for the direct cross-coupling of benzyl alcohols with C-nucleophiles under solvent-free reaction conditions (SFRC). The protocol is metal-free, and air- and water-tolerant, providing a large-scale synthesis with almost quantitative yields.

引用

页数：8

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