Direct C-4 alkylation of quinazoline N-oxides with ethers via an oxidative cross-coupling reaction under metal-free conditions

被引：19
|
作者：
Yang, Qin
Lou, Minhao
Yin, Zhijian
Deng, Zhihong
Ding, Qiuping [1 ]
Peng, Yiyuan [1 ]
机构：
[1] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 45期
基金：
中国国家自然科学基金;
关键词：
C-H ARYLATION; ONE-STEP CONVERSION; EFFICIENT ROUTE; QUINOLINE; BONDS; ARYL; ALKENES; MILD; FUNCTIONALIZATION; ARYLHYDRAZINES;
D O I：
10.1039/c8ob01429a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient protocol for the direct C-4 alkylation of quinazoline-3-oxides via radical oxidative coupling between quinazoline 3-oxides and ethers in the presence of TBHP was developed. The reaction proceeded smoothly under metal-free conditions, which provided quinazoline-containing heterocyclic molecules in moderate to good yields.
引用
收藏
页码：8724 / 8731
页数：9
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