Direct C-4 alkylation of quinazoline N-oxides with ethers via an oxidative cross-coupling reaction under metal-free conditions

被引：19

作者：

Yang, Qin

Lou, Minhao

Yin, Zhijian

Deng, Zhihong

Ding, Qiuping ^{[1
]}

Peng, Yiyuan ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 45期

基金：

中国国家自然科学基金;

关键词：

C-H ARYLATION; ONE-STEP CONVERSION; EFFICIENT ROUTE; QUINOLINE; BONDS; ARYL; ALKENES; MILD; FUNCTIONALIZATION; ARYLHYDRAZINES;

D O I：

10.1039/c8ob01429a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient protocol for the direct C-4 alkylation of quinazoline-3-oxides via radical oxidative coupling between quinazoline 3-oxides and ethers in the presence of TBHP was developed. The reaction proceeded smoothly under metal-free conditions, which provided quinazoline-containing heterocyclic molecules in moderate to good yields.

引用

页码：8724 / 8731

页数：9

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