HPLC-API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process

被引：91

作者：

Korfmacher, WA ^{[1
]}

Cox, KA ^{[1
]}

Bryant, MS ^{[1
]}

Veals, J ^{[1
]}

Ng, K ^{[1
]}

Watkins, R ^{[1
]}

Lin, CC ^{[1
]}

机构：

[1] SCHERING PLOUGH CORP,RES INST,DEPT PHARMACOL,KENILWORTH,NJ 07033

来源：

DRUG DISCOVERY TODAY | 1997年 / 2卷 / 12期

关键词：

D O I：

10.1016/S1359-6446(97)01121-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

HPLC combined with atmospheric pressure ionization (API) mass spectrometry (MS) has become a very useful tool in the pharmaceutical industry. The technique of HPLC-API/MS/MS is becoming very important for both drug discovery and drug development programs. In the drug discovery area, it has three major uses: (1) rapid, quantitative method development, (2) metabolite identification, and (3) multi-drug analysis. The sensitivity of the API source and the selectivity provided by tandem mass spectrometry (MS/MS) enable rapid, quantitative method development for drugs in plasma. Early information on the metabolism of candidate drugs can guide structural modifications, thereby improving the activity and/or bioavailability.

引用

页码：532 / 537

页数：10

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