Enantioselective addition of diethylzinc to a N-diphenylphosphinoylimine employing cinchona alkaloids as chiral ligands

被引：20

作者：

Beresford, KJM ^{[1
]}

机构：

[1] De Montfort Univ, Sch Pharm, Leicester LE1 9BH, Leics, England

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 40期

关键词：

N-diphenylphospinoylimine; cinchona alkaloids; diethylzinc; enantioselective addition;

D O I：

10.1016/S0040-4039(02)01669-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of cinchona alkaloids to promote the addition of diethylzine to P,P-diphenyl-N-(phenylmethylene)phosphinic amide has been examined. Using cinchonine and cinchonidine as ligands, the S and R enantiomers of N-(1-phenylpropyl)-P,P-diphenylphosphinic amide were prepared in good yield with up to 93% ee. The reaction was shown to proceed with catalytic amounts of ligand. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7175 / 7177

页数：3

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