Enantioselective addition of diethylzinc to a N-diphenylphosphinoylimine employing cinchona alkaloids as chiral ligands

被引：20
|
作者：
Beresford, KJM [1 ]
机构：
[1] De Montfort Univ, Sch Pharm, Leicester LE1 9BH, Leics, England
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 40期
关键词：
N-diphenylphospinoylimine; cinchona alkaloids; diethylzinc; enantioselective addition;
D O I：
10.1016/S0040-4039(02)01669-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The use of cinchona alkaloids to promote the addition of diethylzine to P,P-diphenyl-N-(phenylmethylene)phosphinic amide has been examined. Using cinchonine and cinchonidine as ligands, the S and R enantiomers of N-(1-phenylpropyl)-P,P-diphenylphosphinic amide were prepared in good yield with up to 93% ee. The reaction was shown to proceed with catalytic amounts of ligand. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7175 / 7177
页数：3
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