A simple synthetic route to the preparation of 2-(1-phosphonoalkoxy)ethyl derivatives of heterocyclic bases as novel nucleotide analogs related to PMEA

被引：0
|
作者：
Rosenberg, I
Kralikova, S
机构：
来源：
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1996年 / 61卷
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D O I：
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中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Various 1,3-dioxolanes 9 undergo ring-opening in the presence of triesters of phosphoric acid and Lewis acids under formation of 1-(2-hydroxyethoxy)alkanephosphonates 10. These compounds are the key intermediates for the preparation of novel nucleotide analogs 7 and 8 related to 9-(2-phosphonomethoxyethyl)adenine (PMEA).
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页码：S81 / S84
页数：4
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