The regiospecific c-benzylation of heterocyclic ketene aminals with ethyl 2-(bromomethyl)benzoate:: A simple route to 1H-1midazo[1,2-b][2]benzazepin-5-one derivatives

被引：0
|
作者：
Xu, ZH [1 ]
Jie, YF [1 ]
Wang, MX [1 ]
Huang, ZT [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2002年 / 04期
关键词：
heterocyclic ketene aminals; ethyl 2-(bromomethyl)benzoate; 1H-imidazo[1,2-b][2]benzazepin-5-one;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Heterocyclic ketene aminals reacted with ethyl 2-(bromomethyl)benzoate in refluxing acetonitrile to afford the C-benzylated products that underwent intramolecular cyclocondensation reaction to produce epsilon-lactam fused heterocyclic compounds. The heterocyclic ring size effect on the reaction was discussed.
引用
收藏
页码：523 / 527
页数：5
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