A simple synthetic route to the preparation of 2-(1-phosphonoalkoxy)ethyl derivatives of heterocyclic bases as novel nucleotide analogs related to PMEA

被引：0

作者：

Rosenberg, I

Kralikova, S

机构：

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1996年 / 61卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Various 1,3-dioxolanes 9 undergo ring-opening in the presence of triesters of phosphoric acid and Lewis acids under formation of 1-(2-hydroxyethoxy)alkanephosphonates 10. These compounds are the key intermediates for the preparation of novel nucleotide analogs 7 and 8 related to 9-(2-phosphonomethoxyethyl)adenine (PMEA).

引用

页码：S81 / S84

页数：4

共 24 条

[21] SYNTHETIC SCHISTOSOMICIDES .18. N-(4-[[2-(DIETHYLAMINO)ETHYL]AMINO]-1-NAPHTHYL)AMIDES, N-[5,6,7,8-TETRAHYDRO-4-[(3-PIPERIDINOPROPYL)AMINO]-1-NAPHTHYL]AMIDES, AND RELATED AMIDE AND UREA DERIVATIVES
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[22] [5-(ADENIN-9-YL)-5-DEOXYPENTOFURANOSYL]PHOSPHONATES - A NOVEL TYPE OF NUCLEOTIDE ANALOGS RELATED TO HPMPA .1. DERIVATIVES WITH L-ARABINO, D-ARABINO, 2-DEOXY-L-ERYTHRO AND 2-DEOXY-L-THREO CONFIGURATION
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COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1993, 58 (09) : 2159 - 2179
[23] ANTI-SOLID TUMOR EFFICACY AND PREPARATION OF N-[[1-[[2-(DIETHYLAMINO)ETHYL] AMINO]-9-OXO-9H-THIOXANTHEN-4-YL]METHYL]METHANESULFONAMIDE (WIN-33377) AND RELATED DERIVATIVES (VOL 4, PG 609, 1994)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (09) : 1171 - 1171
[24] [5-(ADENIN-9-YL)-5-DEOXY-L-PENTOFURANOSYL]PHOSPHONATES - A NOVEL TYPE OF NUCLEOTIDE ANALOGS RELATED TO HPMPA .2. SYNTHESIS OF L-RIBO AND L-XYLO CONFIGURATED DERIVATIVES BY RECYCLIZATION OF DIETHYL (5-RS)-[1,2-O-ISOPROPYLIDENE-5-O-METHANESULFONYL-D-PENTOFURANOS-5-C-YL]PHOSPHONATES UNDER ACIDIC CONDITIONS
OTMAR, M
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COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1993, 58 (09) : 2180 - 2196

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